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Both panels show the true SFS \(True\),\ the SFS using genotype calls \(GC\) obtained by always choosing the genotype with the highest posterior probability \(Max \(GC\)\)\ , and when only calling genotypes with a posterior probability of >95% \(GC >0.95\). Notice that genotype-based inferences tend \ to overestimate the amount of singletons. The excess of singletons can be reduced or eliminated by using priors, or filtering pr\ ocesses, that are biased against singletons. However, such procedures will typically tend to introduce other biases.)>> endobj 221 0 obj <> endobj 222 0 obj <95% \(light green\). 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<<>> endobj 940 0 obj <>stream application/pdf doi:10.1038/nrg2986 Rasmus Nielsen Joshua S. Paul Anders Albrechtsen Yun S. Song Nature Reviews Genetics 12, 443 (2011). doi:10.1038/nrg2986 Nature Publishing Group © 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. Genotype and SNP calling from next-generation sequencing data Adobe PDF Library 9.9 © 2011 Nature Publishing Group 10.1038/nrg2986 1471-0064 451 1471-0056 6 Nature Publishing Group permissions@nature.com 443 12 2011-06-01 http://dx.doi.org/10.1038/nrg2986 2011-05-10T14:10:05+05:30 Adobe InDesign CS5 (7.0.4) Nature Reviews Genetics 12, 443 (2011). doi:10.1038/nrg2986 2011-05-13T20:47:39+05:30 2011-05-13T20:47:39+05:30 doi:10.1038/nrg2986 True uuid:5058b5e7-5337-4788-920d-5c749eaed209 uuid:6b98ea6e-6c23-4800-bea1-56dde97d311d endstream endobj 941 0 obj <> endobj xref 0 942 0000000000 65535 f 0000097317 00000 n 0000097961 00000 n 0000106678 00000 n 0000106703 00000 n 0000106728 00000 n 0000135964 00000 n 0000136347 00000 n 0000136726 00000 n 0000136824 00000 n 0000136954 00000 n 0000137368 00000 n 0000137780 00000 n 0000137881 00000 n 0000138013 00000 n 0000138387 00000 n 0000138761 00000 n 0000138862 00000 n 0000138994 00000 n 0000139331 00000 n 0000139667 00000 n 0000139768 00000 n 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Paul Anders Albrechtsen Yun S. Song Nature Reviews Genetics 12, 443 (2011). doi:10.1038/nrg2986 Nature Publishing Group © 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. Genotype and SNP calling from next-generation sequencing data Adobe PDF Library 9.9 © 2011 Nature Publishing Group 10.1038/nrg2986 1471-0064 451 1471-0056 6 Nature Publishing Group permissions@nature.com 443 12 2011-06-01 http://dx.doi.org/10.1038/nrg2986 2011-05-10T14:10:05+05:30 Adobe InDesign CS5 (7.0.4) Nature Reviews Genetics 12, 443 (2011). doi:10.1038/nrg2986 2011-05-16T12:48:23+05:30 2011-05-16T12:48:23+05:30 doi:10.1038/nrg2986 True uuid:5058b5e7-5337-4788-920d-5c749eaed209 uuid:2adbb5d0-79ff-4d8e-8897-eb2ef8ed5d92 endstream endobj xref 0 1 0000000097 65535 f 97 1 0000000000 00001 f 241 1 0000525918 00000 n 243 1 0000526387 00000 n 341 6 0000536355 00000 n 0000536404 00000 n 0000536463 00000 n 0000536512 00000 n 0000536561 00000 n 0000536620 00000 n 348 2 0000536679 00000 n 0000536728 00000 n 351 1 0000536777 00000 n 353 1 0000536826 00000 n 355 1 0000536885 00000 n 357 11 0000536934 00000 n 0000536983 00000 n 0000537116 00000 n 0000537241 00000 n 0000537335 00000 n 0000537384 00000 n 0000537433 00000 n 0000537500 00000 n 0000537555 00000 n 0000537610 00000 n 0000537665 00000 n 883 1 0000537720 00000 n 938 1 0000537774 00000 n 941 1 0000537883 00000 n 943 1 0000538208 00000 n 1020 1 0000538425 00000 n trailer <<144FA69149D196409545FE384A4A65C6>]/Prev 116 >> startxref 544489 %%EOF